[HTML][HTML] Blockade of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor necrosis factor-α leads to synergistic antitumor activity

Z Yuan, G Syrkin, A Adem, R Geha, J Pastoriza… - Cancer gene …, 2013 - nature.com
… the combination of tumor … -tumor necrosis factor-α (AAVP-TNF-α) and/or the orally
administered LCL161, an antagonist of inhibitors of apoptosis proteins (IAPs), enhanced antitumor

[HTML][HTML] Combination of IAP antagonists and TNF-α-armed oncolytic viruses induce tumor vascular shutdown and tumor regression

ST Beug, SJ Pichette, M St-Jean, J Holbrook… - Molecular Therapy …, 2018 - cell.com
… TNF-α would lead to an enhanced anti-cancer response. The … synergy with TNF-α-armed
oncolytic VSV in combination with … of TNF-α-blocking antibodies did not rescue cell death in …

Targeting tumor vasculature using adeno-associated virus phage vectors coding tumor necrosis factor-α

Z Yuan, J Pastoriza, T Quinn, SK Libutti - Gene Therapy of Cancer, 2014 - Elsevier
inhibition resulted in significant antitumor effectcombination of antagonists of IAPs and
AAVP–TNF-α anti-angiogenic gene therapy has a synergistic efficacy in tumor cells and the tumor

IAP antagonists induce anti-tumor immunity in multiple myeloma

M Chesi, NN Mirza, VM Garbitt, ME Sharik, AC Dueck… - Nature medicine, 2016 - nature.com
… By contrast, we observed no synergism between LCL161 … We found that blocking type-I IFN
signaling on both tumor and … There is an apparent paradox between the anti-tumor activity of …

[PDF][PDF] Gene Therapy of Cancer

TTVU Adeno-Associated, N Factor-α - 2014 - researchgate.net
inhibition resulted in significant antitumor effectcombination of antagonists of IAPs and
AAVP–TNF-α anti-angiogenic gene therapy has a synergistic efficacy in tumor cells and the tumor

Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis

Y Dai, M Liu, W Tang, J DeSano, E Burstein… - Clinical cancer …, 2008 - AACR
… -molecule IAP inhibitor radiosensitizes HRPC partly due to … are a promising choice for
functionally blocking IAPs and … are consistent in exhibiting a synergistic efficacy when SH-130 is …

Future therapeutic directions for smac-mimetics

E Morrish, G Brumatti, J Silke - Cells, 2020 - mdpi.com
… Overexpression of members of the Inhibitor of APoptosis (IAP… unrelated to safety or anti-tumor
activity (NCT00977067). … cIAPs and the synergistic effects of combining birinapant with …

Targeting innate sensing in the tumor microenvironment to improve immunotherapy

Z Liu, C Han, YX Fu - Cellular & molecular immunology, 2020 - nature.com
… 2 (BCL-2) and inhibitor of apoptosis (IAP), in tumor cells. … Bacillus Calmette–Guérin, of which
the antitumor effect is due … that the antitumor efficacy of these tumor-targeted therapeutics …

IAP proteins as targets for drug development in oncology

L Dubrez, J Berthelet, V Glorian - OncoTargets and therapy, 2013 - Taylor & Francis
antitumoral activity in the randomized Phase 2 studies in pancreatic adenocarcinoma, when
combined … FerreiraCGvan der ValkPSpanSWExpression of X-linked inhibitor of apoptosis as …

Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance

A Shapira, YD Livney, HJ Broxterman… - Drug resistance updates, 2011 - Elsevier
… Hence, in this study, a synergistic tumor growth inhibition of c-… upon these nanovehicles a
synergistic antitumor activity. A … combinations of CRads armed with genes aimed at blocking